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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrimidine

  • CAS No. 67139-22-4

  • Cat. No. CS-D0069
  • Molecule weight123.16
  • Purity≥95%
  • MDL No.MFCD08273903

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrimidine|CS-D0069

Structure of 67139-22-4

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General Information

  • CAS No. 67139-22-4
  • Cat. No. CS-D0069
  • Purity ≥95%
  • MDL No. MFCD08273903
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) imidazo[1,2-a]pyrimidine, 5,6,7,8-tetrahydro-
  • SMILES C12=NC=CN1CCCN2

Description

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrimidine delivers a saturated heterocyclic scaffold with enhanced metabolic stability and improved solubility compared to its aromatic counterpart. This bench-stable core integrates readily into medicinal chemistry libraries, serving as a key building block for kinase inhibitors and CNS-targeted compounds.

Application

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of imidazopyrimidine-based scaffolds found in kinase inhibitors and antiviral agents. Its stable, saturated core exhibits favorable functional group tolerance and facilitates efficient derivatization via electrophilic substitution or transition-metal-catalyzed coupling. The compound functions as a key intermediate in the construction of bioactive molecules under standard synthetic conditions.

Synthesis

  • Route1

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1170 - 1176

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.6987
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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