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CS-W001157 4
Total: USD 88.00

5-Fluoropyrimidine

  • CAS No. 675-21-8

  • Cat. No. CS-W019203
  • Purity≥98%
  • MDL No.MFCD06658278
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Fluoropyrimidine|CS-W019203

Structure of 675-21-8

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Description

5-Fluoropyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and targeted electronic effects. This bench-stable compound integrates readily into nucleoside analogs and bioactive molecules, where its fluorinated ring system modulates reactivity and binding affinity.

Application

5-Fluoropyrimidine serves as a key building block in medicinal chemistry, enabling site-specific functionalization via nucleophilic substitution at the C5 position. Its high reactivity and bench stability facilitate efficient incorporation into heterocyclic scaffolds, including antiviral and anticancer agents. The fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable for optimizing drug candidates through targeted derivatization.

General Information

  • CAS No. 675-21-8
  • Cat. No. CS-W019203
  • Purity ≥98%
  • MDL No. MFCD06658278
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃FN₂
  • Molecular Weight 98.08
  • Synonym(s) Pyrimidine, 5-fluoro-
  • SMILES FC1=CN=CN=C1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   0.6157
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group :
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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