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Structure of 67751-14-8
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4-Dimethylamino-2-oxobut-3-enoic acid ethyl ester features a conjugated enone system flanked by an electron-rich dimethylamino group, enabling efficient Michael additions and Diels-Alder reactions. This bench-stable, moisture-tolerant ester integrates readily into complex synthetic sequences, delivering high functional group compatibility and predictable reactivity in multistep organic synthesis.
4-Dimethylamino-2-oxobut-3-enoic acid ethyl ester serves as a versatile Michael acceptor and enolizable β-ketoester scaffold, enabling efficient construction of substituted pyrroles, γ-lactams, and heterocyclic systems under mild conditions. Its conjugated enone functionality facilitates nucleophilic addition and condensation reactions with amines, thiols, and carbon nucleophiles, while the ethyl ester group supports downstream derivatization. The dimethylamino substituent enhances electrophilicity at the β-carbon and improves solubility in common organic solvents. This compound exhibits excellent bench stability and is readily purified by column chromatography, making it ideal for iterative synthesis campaigns in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: