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CS-W001157 4
Total: USD 88.00

(5-Chloropyridin-2-yl)methanamine

  • CAS No. 67938-76-5

  • Cat. No. CS-0113075
  • Purity≥96%
  • MDL No.MFCD10697658

*For research and further manufacturing use only, not for direct human use.

(5-Chloropyridin-2-yl)methanamine|CS-0113075

Structure of 67938-76-5

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General Information

  • CAS No. 67938-76-5
  • Cat. No. CS-0113075
  • Purity ≥96%
  • MDL No. MFCD10697658
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂
  • Molecular Weight None
  • Synonym(s) 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE
  • SMILES NCC1=NC=C(Cl)C=C1

Description

(5-Chloropyridin-2-yl)methanamine features a pyridine ring bearing a chloro substituent at the 5-position and a primary amine group at the 2-position, enabling direct functionalization in synthetic pathways. The electron-deficient heterocycle enhances reactivity in nucleophilic substitution processes. This bench-stable, moisture-tolerant amine serves as a key scaffold for medicinal chemistry and ligand design.

Application

(5-Chloropyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its ortho-chloro functionality permits palladium-catalyzed cross-coupling reactions, while the primary amine group facilitates conjugation via acylation, reductive amination, or salt formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS06,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P310-P330-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.1937
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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