Lot numbers can be found on the outside label of a product:
5'-O-DMT-N2-ibu-dG
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CAS No. 68892-41-1
- Cat. No. CS-W011418
- Purity≥95%
- MDL No.MFCD00010059
*For research and further manufacturing use only, not for direct human use.
Structure of 68892-41-1
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General Information
- CAS No. 68892-41-1
- Cat. No. CS-W011418
- Purity ≥95%
- MDL No. MFCD00010059
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₃₅H₃₇N₅O₇
- Molecular Weight 639.70
- Synonym(s) N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine
- SMILES O[C@H]1C[C@H](N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
Description
5'-O-DMT-N2-ibu-dG is a protected deoxyguanosine derivative featuring a 5'-O-dimethoxytrityl group and a N2-isobutyryl modification. This combination enhances stability during oligonucleotide synthesis, enabling efficient incorporation into DNA strands with improved solubility and reduced side reactions under standard conditions.
Application
5'-O-DMT-N2-ibu-dG serves as a key building block for the synthesis of oligonucleotides containing modified guanine residues. The DMT group provides robust protection at the 5'-hydroxyl, enabling efficient purification via reverse-phase chromatography. The N2-isobutyryl modification enhances stability and facilitates selective deprotection during solid-phase synthesis. This derivative enables reliable incorporation of functionalized guanine units into DNA strands, supporting applications in antisense technology and nucleic acid therapeutics.
Synthesis
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References
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McGee, Danny P. C.; Martin, John C.; Webb, Austin S. Synthesis, 1983 , # 7 p. 540 - 541
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Route2
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160107-22-2 - ~73%
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In-stock
68892-41-1
References
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Brill, Wolfgang K.-D. Tetrahedron Letters, 1994 , vol. 35, # 19 p. 3041 - 3044
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Route3
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In-stock
961-07-9 - ~%
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In-stock
68892-41-1
References
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Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 9 p. 916 - 919
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 149.82
- LogP 4.3884
- H_Acceptors 10
- H_Donors 3
- Rotatable_Bonds 11
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Other Classifications
- Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Protected Nucleosides
- Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs
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Key Words
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