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CS-W001157 4
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6-Amino-1H-indazole

  • CAS No. 6967-12-0

  • Cat. No. CS-W001975
  • Purity≥97%
  • MDL No.MFCD00005696

*For research and further manufacturing use only, not for direct human use.

6-Amino-1H-indazole|CS-W001975

Structure of 6967-12-0

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General Information

  • CAS No. 6967-12-0
  • Cat. No. CS-W001975
  • Purity ≥97%
  • MDL No. MFCD00005696
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) indazol-6-ylamine
  • SMILES Nc1ccc2c(c1)[nH]nc2

Description

6-Amino-1H-indazole is a bench-stable, electron-rich heterocycle featuring a strategically positioned amino group that enhances solubility and reactivity. This scaffold integrates readily into medicinal chemistry campaigns, serving as a key pharmacophore in kinase inhibitors and bioactive molecule design.

Application

6-Amino-1H-indazole serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its amino group facilitates direct derivatization, while the indazole core provides robust scaffold stability and favorable pharmacokinetic properties. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput screening campaigns and scalable process development.

Synthesis

  • Route1

    References

    • Quinn, John F.; Bryant, Cole E.; Golden, Kathryn C.; Gregg, Brian T. Tetrahedron Letters, 2010 , vol. 51, # 5 p. 786 - 789
  • Route2

    References

    • Chemische Berichte, , vol. 23, p. 3642 Chemische Berichte, , vol. 25, p. 3152
  • Route3
    • null|null
      64-17-5
    • null|null
      7783-06-4
    • In-stock
      6-Nitroindazole|CS-M3172
      7597-18-4
    • ~%
    • In-stock
      6-Amino-1H-indazole|CS-W001975
      6967-12-0

    References

    • Chemische Berichte, , vol. 23, p. 3642 Chemische Berichte, , vol. 25, p. 3152

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.1451
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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