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CS-W001157 4
Total: USD 88.00

6-Methyl-1H-indazole

  • CAS No. 698-24-8

  • Cat. No. CS-0045049
  • Purity≥98%
  • MDL No.MFCD07781625

*For research and further manufacturing use only, not for direct human use.

6-Methyl-1H-indazole|CS-0045049

Structure of 698-24-8

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General Information

  • CAS No. 698-24-8
  • Cat. No. CS-0045049
  • Purity ≥98%
  • MDL No. MFCD07781625
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) 6-Methyl (1H)Indazole
  • SMILES CC1=CC2=C(C=C1)C=NN2

Description

6-Methyl-1H-indazole is a heterocyclic compound featuring a methyl-substituted indazole core, offering enhanced solubility and stability under standard conditions. This scaffold integrates readily into medicinal chemistry campaigns, serving as a key pharmacophore in kinase inhibitor design and bioactive molecule development.

Application

6-Methyl-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functionalization at the indazole core. Its methyl group provides a site for directed ortho-metalation and supports metabolic stability in drug candidates. The compound exhibits excellent bench stability, facilitates efficient derivatization under mild conditions, and functions as a key intermediate in the synthesis of kinase inhibitors and other targeted therapeutics.

Synthesis

  • Route1
    • null|null
      343791-82-2
    • ~%
    • In-stock
      6-Methyl-1H-indazole|CS-0045049
      698-24-8

    References

    • Liebigs Annalen der Chemie, , # 6 p. 908 - 927
  • Route2
    • null|null
      95-78-3
    • ~%
    • In-stock
      6-Methyl-1H-indazole|CS-0045049
      698-24-8

    References

    • Liebigs Annalen der Chemie, , # 6 p. 908 - 927
  • Route3
    • N-(2,5-dimethylphenyl)benzamide|CS-0555770
      71114-52-8
    • ~%
    • In-stock
      6-Methyl-1H-indazole|CS-0045049
      698-24-8

    References

    • Chemische Berichte, , vol. 53, p. 1213,1216, 1227

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.87132
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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