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Structure of 705-28-2
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1-Ethynyl-3-(trifluoromethyl)benzene features a trifluoromethyl group positioned ortho to an ethynyl substituent, creating a highly electron-deficient aromatic system. This configuration enhances reactivity in copper-catalyzed coupling reactions, enabling efficient incorporation into complex molecular architectures. The molecule exhibits excellent stability under standard bench conditions and facilitates seamless integration into functionalized scaffolds for materials science and pharmaceutical development.
1-Ethynyl-3-(trifluoromethyl)benzene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated arylalkynes. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the terminal alkyne facilitates Sonogashira, Glaser, and click-type transformations. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for constructing complex scaffolds in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H302-H312-H332
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: