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Structure of 710-18-9
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1-Methoxy-4-(trifluoromethoxy)benzene features a para-substituted aromatic ring with complementary electron-donating and electron-withdrawing groups, enabling robust participation in cross-coupling reactions. The trifluoromethoxy moiety imparts enhanced metabolic stability and lipophilicity, while the methoxy group provides a reliable handle for further functionalization under standard conditions.
1-Methoxy-4-(trifluoromethoxy)benzene serves as a versatile aryl building block in medicinal chemistry and materials science, enabling efficient functionalization via Suzuki-Miyaura and Ullmann coupling reactions. Its dual electron-withdrawing trifluoromethoxy and electron-donating methoxy groups provide balanced reactivity and enhanced metabolic stability. The compound exhibits excellent bench stability, simple purification by column chromatography, and compatibility with a broad range of synthetic transformations.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H302+H312+H332-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: