(2,3-Difluorophenyl)methanamine

Name: (2,3-Difluorophenyl)methanamine
Brand: ChemScene
Availability: InStock
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CAS No. 72235-51-9
Cat. No. CS-W018260
Purity≥97%
MDL No.MFCD00070793

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2,3-Difluorophenyl)methanamine|CS-W018260

Structure of 72235-51-9

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General Information

CAS No. 72235-51-9
Cat. No. CS-W018260
Purity ≥97%
MDL No. MFCD00070793
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇F₂N
Molecular Weight 143.14
Synonym(s) Difluorobenzylamine1
SMILES NCC1=CC=CC(F)=C1F

Description

(2,3-Difluorophenyl)methanamine is a bench-stable arylalkylamine featuring two fluorine atoms at the ortho and meta positions of the phenyl ring. This electron-deficient aromatic system enhances metabolic stability while maintaining favorable solubility for use in medicinal chemistry. The primary amine group enables direct incorporation into diverse molecular architectures via coupling reactions, making it a valuable scaffold for drug discovery.

Application

(2,3-Difluorophenyl)methanamine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles and drug-like scaffolds. Its difluorinated aromatic core enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates straightforward derivatization via amidation, alkylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it well-suited for iterative synthesis and lead optimization workflows.

Synthesis

Route1
- 923845-93-6
- ~62%
- In-stock
  
  72235-51-9
References
- THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER Patent: WO2009/26248 A2, 2009 ; Location in patent: Page/Page column 107 ;
Route2
- In-stock
  
  21524-39-0
- ~%
- In-stock
  
  72235-51-9
References
- Organic Letters, , vol. 1, # 2 p. 183 - 185

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 1.4235
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2,3-Difluorophenyl)methanamine

CAS No. 72235-51-9

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