2-Amino-N,N-dimethylacetamide hydrochloride

Name: 2-Amino-N,N-dimethylacetamide hydrochloride
Brand: ChemScene
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CAS No. 72287-77-5
Cat. No. CS-W003959
Molecule weight138.60
Purity≥97%
MDL No.MFCD08060117

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Amino-N,N-dimethylacetamide hydrochloride|CS-W003959

Structure of 72287-77-5

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General Information

CAS No. 72287-77-5
Cat. No. CS-W003959
Purity ≥97%
MDL No. MFCD08060117
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₁₁ClN₂O
Molecular Weight 138.60
Synonym(s) N,N-dimethylglycinamide hydrochloride
SMILES NCC(=O)N(C)C.Cl

Description

2-Amino-N,N-dimethylacetamide hydrochloride features a protonated amine enabling efficient salt formation, enhancing solubility and stability in aqueous systems. This bench-stable derivative integrates readily into peptide coupling workflows and serves as a key intermediate in bioactive molecule synthesis.

Application

2-Amino-N,N-dimethylacetamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to amide-linked scaffolds. The protonated amine enhances solubility and facilitates salt formation, while the N,N-dimethyl group provides steric protection and metabolic stability. It functions reliably in coupling reactions, nucleophilic substitutions, and heterocycle synthesis, offering excellent bench stability and straightforward purification.

Synthesis

Route1
- 72287-76-4
- ~%
- In-stock
  
  72287-77-5
References
- Journal of the American Chemical Society, , vol. 115, # 10 p. 4228 - 4245
Route2
- In-stock
  
  3392-07-2
- 124-40-3
- ~63%
- In-stock
  
  72287-77-5
References
- Ikenishi; Kitagawa; Hirai Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 609 - 617

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 46.33
LogP -0.5449
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Fatty chain compounds

Key Words

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2-Amino-N,N-dimethylacetamide hydrochloride

CAS No. 72287-77-5

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