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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-pyridinecarboxaldehyde

  • CAS No. 72716-87-1

  • Cat. No. CS-D1632
  • Purity≥98%
  • MDL No.MFCD06410680
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-pyridinecarboxaldehyde|CS-D1632

Structure of 72716-87-1

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Description

2-Methoxy-4-pyridinecarboxaldehyde features a pyridine ring bearing both aldehyde and methoxy substituents at the 4- and 2-positions, respectively. This electron-deficient heterocyclic scaffold enables selective coupling reactions in synthetic organic chemistry. The aldehyde group facilitates nucleophilic addition, while the methoxy moiety enhances solubility and modulates electronic properties. This compound serves as a key building block for pharmaceutical intermediates and functional materials.

Application

2-Methoxy-4-pyridinecarboxaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to pyridine-based pharmacophores. Its aldehyde functionality facilitates nucleophilic additions, reductive aminations, and condensation reactions under mild conditions. The ortho-methoxy group enhances solubility and modulates electronic properties, while the pyridine ring provides a stable scaffold amenable to further functionalization. Bench-stable and readily purified by crystallization or flash chromatography, it functions effectively in multistep synthetic sequences requiring high reproducibility and scalability.

General Information

  • CAS No. 72716-87-1
  • Cat. No. CS-D1632
  • Purity ≥98%
  • MDL No. MFCD06410680
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 2-Methoxyisonicotinaldehyde; 2-Methoxypyridin-4-carboxaldehyde; 4-pyridinecarboxaldehyde, 2-methoxy-
  • SMILES O=CC1=CC(OC)=NC=C1

Computational Chemistry Data

  • TPSA   39.19
  • LogP   0.9027
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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