Lot numbers can be found on the outside label of a product:
4'-Iodo-[1,1'-biphenyl]-4-amine
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CAS No. 7285-77-0
- Cat. No. CS-0157512
- Purity≥95%
- MDL No.MFCD00545088
*For research and further manufacturing use only, not for direct human use.
![4'-Iodo-[1,1'-biphenyl]-4-amine|CS-0157512](https://file.chemscene.com/productPIC/CS-0157512.gif)
Structure of 7285-77-0
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General Information
- CAS No. 7285-77-0
- Cat. No. CS-0157512
- Purity ≥95%
- MDL No. MFCD00545088
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₀IN
- Molecular Weight 295.12
- Synonym(s) 4-Amino-4'-iodobiphenyl
- SMILES C1=C(C=CC(=C1)I)C2=CC=C(C=C2)N
Description
4'-Iodo-[1,1'-biphenyl]-4-amine features a terminal amine paired with a para-iodinated aryl group, enabling direct coupling in cross-coupling reactions. This electron-deficient biphenyl scaffold offers enhanced reactivity in palladium-catalyzed transformations and exhibits robust stability under standard reaction conditions.
Application
4'-Iodo-[1,1'-biphenyl]-4-amine serves as a versatile building block for Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The iodide group exhibits high reactivity and compatibility with palladium catalysts, while the primary amine functions as a handle for further derivatization or conjugation. Its bench-stable solid form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
Synthesis
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Route1
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In-stock
29170-08-9 - ~70%
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In-stock
7285-77-0
References
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Makarov, Alexander Yu; Bagryanskaya, Irina Yu; Gatilov, Yuri V.; Mikhalina, Tatiana V.; Shakirov, Makhmut M.; Shchegoleva, Lyudmila N.; Zibarev, Andrey V. Heteroatom Chemistry, 2001 , vol. 12, # 7 p. 563 - 576
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References
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Zhang, Yawei; Starynowicz, Przemyslaw; Christoffers, Jens European Journal of Organic Chemistry, 2008 , # 20 p. 3488 - 3495
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Route3
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92-52-4 - ~%
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In-stock
7285-77-0
References
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You; Brezzell; Das; Hooberman; Sinsheimer Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure, 1994 , vol. 320, # 1-2 p. 45 - 58
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 26.02
- LogP 3.5404
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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