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CS-W001157 4
Total: USD 88.00

1-(4-Amino-3-fluorophenyl)ethanone

  • CAS No. 73792-22-0

  • Cat. No. CS-W019521
  • Molecule weight153.15
  • Purity≥98%
  • MDL No.MFCD12032124

*For research and further manufacturing use only, not for direct human use.

1-(4-Amino-3-fluorophenyl)ethanone|CS-W019521

Structure of 73792-22-0

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General Information

  • CAS No. 73792-22-0
  • Cat. No. CS-W019521
  • Purity ≥98%
  • MDL No. MFCD12032124
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO
  • Molecular Weight 153.15
  • Synonym(s) 4-Amino-3-Fluoroacetophenone
  • SMILES CC(C1=CC=C(N)C(F)=C1)=O

Description

1-(4-Amino-3-fluorophenyl)ethanone features a fluorinated aromatic ring paired with a primary amine and ketone functionality, enabling direct incorporation into diverse synthetic scaffolds. This electron-deficient aryl ketone serves as a key intermediate in medicinal chemistry, facilitating the construction of bioactive molecules through nucleophilic addition or coupling reactions under standard conditions.

Application

1-(4-Amino-3-fluorophenyl)ethanone serves as a key building block for fluorinated aryl ketones in medicinal chemistry. Its amino and fluoro substituents enable diverse downstream functionalization, including coupling reactions and heterocycle formation. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for use in multi-step synthesis of API candidates and bioactive scaffolds.

Synthesis

  • Route1
    • null|null
      111-34-2
    • In-stock
      2-Fluoro-4-iodoaniline|CS-W002069
      29632-74-4
    • ~35%
    • In-stock
      1-(4-Amino-3-fluorophenyl)ethanone|CS-W019521
      73792-22-0

    References

    • AMOREPACIFIC CORPORATION Patent: WO2006/101318 A1, 2006 ; Location in patent: Page/Page column 44; 83-84 ; WO 2006/101318 A1
  • Route2
    • N-(4-Acetyl-2-fluorophenyl)acetamide|CS-1193283
      85117-88-0
    • ~82%
    • In-stock
      1-(4-Amino-3-fluorophenyl)ethanone|CS-W019521
      73792-22-0

    References

    • Kruger; Keck; Noll; Pieper Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
  • Route3
    • null|null
      348-54-9
    • ~%
    • In-stock
      1-(4-Amino-3-fluorophenyl)ethanone|CS-W019521
      73792-22-0

    References

    • Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335-H360
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.6105
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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