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Methyl 6-amino-1H-indazole-7-carboxylate

  • CAS No. 73907-98-9

  • Cat. No. CS-0043026
  • Purity≥97%
  • MDL No.MFCD20691477

*For research and further manufacturing use only, not for direct human use.

Methyl 6-amino-1H-indazole-7-carboxylate|CS-0043026

Structure of 73907-98-9

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General Information

  • CAS No. 73907-98-9
  • Cat. No. CS-0043026
  • Purity ≥97%
  • MDL No. MFCD20691477
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉N₃O₂
  • Molecular Weight 191.19
  • Synonym(s) 1H-Indazole-7-carboxylic acid, 6-amino-, methyl ester
  • SMILES COC(=O)C1=C2NN=CC2=CC=C1N

Description

Methyl 6-amino-1H-indazole-7-carboxylate features a planar indazole core with strategically positioned amino and ester functionalities. The electron-rich aromatic system enables efficient coupling reactions, while the methyl ester group facilitates selective derivatization. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates.

Application

Methyl 6-amino-1H-indazole-7-carboxylate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 6-amino position and orthogonal manipulation of the ester group. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of indazole-based scaffolds. The molecule functions as a key intermediate in constructing bioactive heterocycles, particularly for kinase inhibitors and targeted therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   81
  • LogP   0.9317
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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