Lot numbers can be found on the outside label of a product:
1-Bromo-2,5-difluoro-3-nitrobenzene
-
CAS No. 741721-51-7
- Cat. No. CS-W018872
- Purity≥96%
- MDL No.MFCD18205960
*For research and further manufacturing use only, not for direct human use.
Structure of 741721-51-7
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 741721-51-7
- Cat. No. CS-W018872
- Purity ≥96%
- MDL No. MFCD18205960
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₂BrF₂NO₂
- Molecular Weight 237.99
- Synonym(s) 1-bromo-2,5-difluoro-3-nitro-benzene
- SMILES [O-][N+](=O)C1=CC(F)=CC(Br)=C1F
Description
1-Bromo-2,5-difluoro-3-nitrobenzene features a trifunctional aromatic core with orthogonal reactivity. The bromine serves as a reliable coupling handle in cross-coupling reactions, while the electron-deficient ring enhances susceptibility to nucleophilic substitution. The para-fluorine and meta-nitro groups stabilize the intermediate and direct regioselective functionalization. This compound enables efficient access to complex fluorinated heterocycles and bioactive scaffolds under standard conditions.
Application
1-Bromo-2,5-difluoro-3-nitrobenzene serves as a versatile building block for the synthesis of fluorinated heterocycles and functionalized aryl scaffolds. Its orthogonal reactivity—combining electrophilic bromine with electron-withdrawing nitro and fluorine substituents—enables palladium-catalyzed cross-couplings, nucleophilic aromatic substitution, and sequential functionalization. Bench-stable and compatible with standard purification methods, it facilitates efficient access to complex fluorinated intermediates in medicinal chemistry and materials science applications.
Synthesis
-
Route1
-
In-stock
741721-49-3 -
741721-50-6 - ~37%
-
In-stock
741721-51-7
References
-
WARNER-LAMBERT COMPANY LLC Patent: WO2004/69832 A2, 2004 ; Location in patent: Page 134 ;
-
-
Route2
-
In-stock
741721-49-3
- ~37%
-
In-stock
741721-51-7
References
-
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
-
-
Route3
-
In-stock
2991-28-8 - ~%
-
In-stock
741721-51-7
References
-
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 43.14
- LogP 2.6355
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 1-Bromo-2,5-difluoro-3-nitrobenzene sigma1-Bromo-2,5-difluoro-3-nitrobenzene manufacturer1-Bromo-2,5-difluoro-3-nitrobenzene price1-Bromo-2,5-difluoro-3-nitrobenzene structure1-Bromo-2,5-difluoro-3-nitrobenzene SDSbuy 1-Bromo-2,5-difluoro-3-nitrobenzene1-Bromo-2,5-difluoro-3-nitrobenzene supplier1-Bromo-2,5-difluoro-3-nitrobenzene uses1-Bromo-2,5-difluoro-3-nitrobenzene molecular weightprice of 1-Bromo-2,5-difluoro-3-nitrobenzene1-Bromo-2,5-difluoro-3-nitrobenzene chemical name formula of 1-Bromo-2,5-difluoro-3-nitrobenzene