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CS-W001157 4
Total: USD 88.00

3-Fluoro-2-methoxybenzaldehyde

  • CAS No. 74266-68-5

  • Cat. No. CS-0007666
  • Purity≥97%
  • MDL No.MFCD04112486

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methoxybenzaldehyde|CS-0007666

Structure of 74266-68-5

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General Information

  • CAS No. 74266-68-5
  • Cat. No. CS-0007666
  • Purity ≥97%
  • MDL No. MFCD04112486
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 1-Fluoro-3-formyl-2-methoxybenzene
  • SMILES O=CC1=CC=CC(F)=C1OC

Description

3-Fluoro-2-methoxybenzaldehyde delivers a strategically positioned fluorine and methoxy group adjacent to the aldehyde functionality, enabling tailored electronic and steric modulation in synthetic intermediates. This bench-stable compound integrates readily into complex molecular architectures under standard conditions.

Application

3-Fluoro-2-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity through its fluorinated aromatic ring and methoxy-substituted aldehyde functionality. Its bench-stable nature and compatibility with standard coupling reactions enable efficient construction of complex heterocycles and biaryl scaffolds. The molecule functions effectively in Suzuki-Miyaura, Ullmann, and nucleophilic addition protocols, facilitating rapid access to diverse pharmacophores.

Synthesis

  • Route1
    • In-stock
      3-Fluorosalicylaldehyde|CS-W007698
      394-50-3
    • null|null
      74-88-4
    • ~85%
    • In-stock
      3-Fluoro-2-methoxybenzaldehyde|CS-0007666
      74266-68-5

    References

    • ELI LILLY AND COMPANY Patent: WO2009/140448 A1, 2009 ; Location in patent: Page/Page column 38-39 ;
  • Route2
    • In-stock
      3-Fluorosalicylaldehyde|CS-W007698
      394-50-3
    • null|null
      77-78-1
    • ~99%
    • In-stock
      3-Fluoro-2-methoxybenzaldehyde|CS-0007666
      74266-68-5

    References

    • ELI LILLY AND COMPANY Patent: WO2004/43904 A1, 2004 ; Location in patent: Page 29 ; WO 2004/043904 A1
  • Route3

    References

    • Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.6468
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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