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tert-Butyl (2-formylphenyl)carbamate

  • CAS No. 74965-38-1

  • Cat. No. CS-0109009
  • Molecule weight221.25
  • Purity≥98%
  • MDL No.MFCD01861809

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2-formylphenyl)carbamate|CS-0109009

Structure of 74965-38-1

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General Information

  • CAS No. 74965-38-1
  • Cat. No. CS-0109009
  • Purity ≥98%
  • MDL No. MFCD01861809
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₃
  • Molecular Weight 221.25
  • Synonym(s) tert-butyl2-formylphenylcarbamate
  • SMILES O=C(OC(C)(C)C)NC1=CC=CC=C1C=O

Description

tert-Butyl (2-formylphenyl)carbamate features a formyl group ortho to a carbamate moiety, enabling direct functionalization in late-stage synthesis. This bench-stable reagent integrates readily into diversification workflows, offering selective reactivity under mild conditions while maintaining compatibility with common protecting groups.

Application

tert-Butyl (2-formylphenyl)carbamate serves as a versatile building block in medicinal chemistry, enabling efficient access to ortho-substituted benzaldehyde derivatives. The carbamate group provides stability and facilitates selective deprotection under mild acidic conditions, while the formyl functionality supports standard transformations including reductive amination, Wittig reactions, and nucleophilic additions. Its bench-stable nature and compatibility with diverse synthetic workflows make it ideal for constructing complex heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.4
  • LogP   2.8461
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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