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CS-W001157 4
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3-(Pyrrolidin-1-yl)propanoic acid

  • CAS No. 76234-38-3

  • Cat. No. CS-0035766
  • Molecule weight143.18
  • Purity≥97%
  • MDL No.MFCD04114076

*For research and further manufacturing use only, not for direct human use.

3-(Pyrrolidin-1-yl)propanoic acid|CS-0035766

Structure of 76234-38-3

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General Information

  • CAS No. 76234-38-3
  • Cat. No. CS-0035766
  • Purity ≥97%
  • MDL No. MFCD04114076
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₂
  • Molecular Weight 143.18
  • Synonym(s) 3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL
  • SMILES C1CCN(C1)CCC(=O)O

Description

3-(Pyrrolidin-1-yl)propanoic acid features a pyrrolidine ring tethered to a propanoic acid chain, delivering enhanced solubility and nucleophilicity. This amine-bearing scaffold integrates readily into bioactive molecule design, particularly in peptide conjugation and medicinal chemistry applications. The electron-donating nature of the pyrrolidine group stabilizes adjacent intermediates during synthetic transformations.

Application

3-(Pyrrolidin-1-yl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide analogs. Its amide-linked pyrrolidine moiety offers favorable solubility and metabolic stability, while the carboxylic acid facilitates conjugation via standard coupling reactions. The molecule exhibits bench stability and compatibility with diverse reaction conditions, supporting efficient functionalization in multi-step syntheses.

Synthesis

  • Route1
    • Methyl 3-pyrrolidinopropionate|CS-0030357
      22041-21-0
    • ~80%
    • In-stock
      3-(Pyrrolidin-1-yl)propanoic acid|CS-0035766
      76234-38-3

    References

    • Groselj, Uros; Kralj, David; Wagger, Jernej; Dahmann, Georg; Stanovnik, Branko; Svete, Jurij Arkivoc, 2012 , vol. 2012, # 3 p. 49 - 65
  • Route2
    • null|null
      123-75-1
    • null|null
      79-10-7
    • ~%
    • In-stock
      3-(Pyrrolidin-1-yl)propanoic acid|CS-0035766
      76234-38-3

    References

    • US4927919 A1, ;
  • Route3

    References

    • European Journal of Medicinal Chemistry, , vol. 46, # 6 p. 2224 - 2235

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   0.5569
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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