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CS-W001157 4
Total: USD 88.00

1H-Pyrrol-1-amine

  • CAS No. 765-39-9

  • Cat. No. CS-W005251
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD00059931

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrol-1-amine|CS-W005251

Structure of 765-39-9

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General Information

  • CAS No. 765-39-9
  • Cat. No. CS-W005251
  • Purity ≥95%
  • MDL No. MFCD00059931
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₂
  • Molecular Weight None
  • Synonym(s) 1-Aminopyrrole
  • SMILES NN1C=CC=C1

Description

1H-Pyrrol-1-amine features a reactive pyrrolidine nitrogen that integrates readily into heterocyclic scaffolds. This bench-stable, moisture-tolerant amine serves as a direct precursor for C–N bond formation and functionalized pyrrole derivatives in synthetic and medicinal chemistry applications.

Application

1H-Pyrrol-1-amine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to nitrogen-containing heterocycles and pharmaceutical scaffolds. Its primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and electrophilic substitution, while the pyrrole ring supports electrophilic aromatic substitution under mild conditions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for multi-step synthesis and process development in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Dey, Sanjeev K.; Lightner, David A. Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9395 - 9397
  • Route2
    • null|null
      109-97-7
    • ~38%
    • In-stock
      1H-Pyrrol-1-amine|CS-W005251
      765-39-9

    References

    • Davis, Larry; Olsen, Gordon E.; Klein, Joseph T.; Kapples, Kevin J.; Huger, Francis P.; et al. J. Med. Chem., 1996 , vol. 39, # 2 p. 582 - 587
  • Route3

    References

    • US2002/58667 A1, ; US 20020058667 A1 US2003/45536 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 3267
Class : 8
Packing Group : Ⅲ
Hazard Statements : H226-H302-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   30.95
  • LogP   0.2019
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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