Lot numbers can be found on the outside label of a product:
2,3,3-Trimethyl-3H-indol-5-amine
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CAS No. 773-63-7
- Cat. No. CS-0152763
- Purity≥95%
- MDL No.MFCD00614246
*For research and further manufacturing use only, not for direct human use.
Structure of 773-63-7
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General Information
- CAS No. 773-63-7
- Cat. No. CS-0152763
- Purity ≥95%
- MDL No. MFCD00614246
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₄N₂
- Molecular Weight 174.24
- Synonym(s) 5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE
- SMILES CC1=NC2=C(C=C(C=C2)N)C1(C)C
Description
2,3,3-Trimethyl-3H-indol-5-amine features a sterically hindered indole core with a primary amine at the 5-position, enabling direct functionalization in synthetic transformations. The methyl groups enhance stability and solubility in organic media, while the electron-rich indole scaffold facilitates coupling reactions under mild conditions. This derivative serves as a robust building block for bioactive heterocycles and fluorescent probes.
Application
2,3,3-Trimethyl-3H-indol-5-amine serves as a versatile building block for indole-based scaffolds in medicinal chemistry. Its electron-rich aromatic core and pendant primary amine facilitate downstream functionalization via amidation, alkylation, or transition-metal-catalyzed coupling. The trimethyl substitution enhances solubility and metabolic stability, while the 3H-indol structure ensures compatibility with standard heterocycle synthesis protocols. Ideal for rapid library generation and lead optimization in CNS-targeted drug discovery.
Synthesis
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Route1
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In-stock
3484-22-8 - ~97%
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In-stock
773-63-7
References
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LABORATOIRES SYNTH-INNOVE Patent: US2012/45851 A1, 2012 ; Location in patent: Page/Page column 14; 18 ;
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Route2
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60-29-7 -
In-stock
3484-22-8
- ~%
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In-stock
773-63-7
References
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DAKO DENMARK A/S Patent: US2011/230664 A1, 2011 ;
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Route3
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In-stock
1640-39-7 - ~%
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In-stock
773-63-7
References
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LABORATOIRES SYNTH-INNOVE Patent: US2012/45851 A1, 2012 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.38
- LogP 2.6524
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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