Tos-PEG3

Name: Tos-PEG3
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 77544-68-4
Cat. No. CS-0066341
Molecule weight304.36
Purity≥96%
MDL No.MFCD18433414

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 77544-68-4

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General Information

CAS No. 77544-68-4
Cat. No. CS-0066341
Purity ≥96%
MDL No. MFCD18433414
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₀O₆S
Molecular Weight 304.36
Synonym(s) None
SMILES OCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Tos-PEG3 features a tosyl group appended to a triethylene glycol chain, offering a robust, moisture-tolerant linker for conjugation. This bifunctional scaffold enables efficient coupling of nucleophiles while maintaining solubility in aqueous and organic media. The PEG spacer provides steric shielding and enhanced bioavailability, making it ideal for peptide modification and probe synthesis under standard conditions.

Application

Tos-PEG3 serves as a versatile bifunctional linker enabling efficient conjugation in peptide and small-molecule synthesis. The tosyl (Tos) group facilitates nucleophilic displacement reactions, while the PEG3 spacer provides enhanced solubility and reduced aggregation. This combination supports reliable purification and stability under standard bench conditions, making it well-suited for building complex architectures in medicinal chemistry and chemical biology workflows.

Synthesis

Route1
- 98-59-9
- In-stock
  
  112-27-6
- ~95%
- In-stock
  
  77544-68-4
References
- Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
Route2
- 98-59-9
- In-stock
  
  112-27-6
- ~90%
- In-stock
  
  77544-68-4
- In-stock
  
  19249-03-7
References
- Bouzide, Abderrahim; Sauve, Gilles Organic Letters, 2002 , vol. 4, # 14 p. 2329 - 2332

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 82.06
LogP 0.72582
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 10

Other Classifications

Building Blocks Functional Group PEG

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Sulfonate

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Hydroxy PEG

Life Science Linker PEG Tosylate

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

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Tos-PEG3

CAS No. 77544-68-4

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