(2R,4R)-1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate

Name: (2R,4R)-1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 778646-95-0
Cat. No. CS-0311475
Purity≥98%
MDL No.MFCD18071303

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(2R,4R)-1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate|CS-0311475

Structure of 778646-95-0

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Description

This chiral piperidine derivative features a tert-butyl-protected amine and methyl-substituted backbone, enabling straightforward functionalization in asymmetric synthesis. The (2R,4R) stereochemistry ensures high diastereoselectivity in downstream transformations, while the dicarboxylate moiety facilitates selective derivatization under mild conditions.

Application

(2R,4R)-1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate serves as a stereochemically defined chiral building block for the synthesis of bioactive piperidine derivatives. The protected amine and dicarboxylate groups enable selective functionalization and orthogonal transformations. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry campaigns.

General Information

CAS No. 778646-95-0
Cat. No. CS-0311475
Purity ≥98%
MDL No. MFCD18071303
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₄
Molecular Weight 258.31
Synonym(s) 1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate
SMILES O=C(N1[C@@H](C(OC)=O)C[C@H](N)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 81.86
LogP 0.8862
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(2R,4R)-1-tert-Butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate

CAS No. 778646-95-0

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