tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate

Name: tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 781649-86-3
Cat. No. CS-M0488
Purity≥98%
MDL No.MFCD13184780

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate|CS-M0488

Structure of 781649-86-3

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General Information

CAS No. 781649-86-3
Cat. No. CS-M0488
Purity ≥98%
MDL No. MFCD13184780
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₄N₄O₂
Molecular Weight 292.38
Synonym(s) 1-Piperidinecarboxylic acid, 4-[(2-aMino-3-pyridinyl)aMino]-, 1,1-diMethylethyl ester
SMILES O=C(OC(C)(C)C)N(CC1)CCC1NC2=CC=CN=C2N

Description

tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate features a piperidine scaffold bearing a pyridinamine handle, enabling direct conjugation in late-stage functionalization. The tert-butyl ester offers bench-stable protection, simplifying purification and handling during synthetic workflows. This building block integrates efficiently into kinase inhibitor scaffolds and other bioactive heterocycles.

Application

tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate serves as a versatile building block for pyridine-containing heterocycles, enabling efficient access to bioactive scaffolds via standard amide coupling, Suzuki-Miyaura, and Buchwald-Hartwig reactions. The protected amine and piperidine core offer excellent functional group tolerance, bench stability, and ease of purification, making it ideal for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

Route1
- In-stock
  
  452-58-4
- 79099-07-3
- ~87%
- In-stock
  
  781649-86-3
References
- Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
Route2
- 1155016-22-0
- ~78%
- In-stock
  
  781649-86-3
References
- Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
Route3
- In-stock
  
  452-58-4
- 79099-07-3
- ~%
- In-stock
  
  781649-86-3
- 1356400-55-9
References
- Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 80.48
LogP 2.4752
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate

CAS No. 781649-86-3

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