2-(Hexahydro-1H-pyrrolizin-7a-yl)acetonitrile

Name: 2-(Hexahydro-1H-pyrrolizin-7a-yl)acetonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 78449-75-9
Cat. No. CS-0308262
Molecule weight150.22
Purity≥98%
MDL No.MFCD19704706

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(Hexahydro-1H-pyrrolizin-7a-yl)acetonitrile|CS-0308262

Structure of 78449-75-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 78449-75-9
Cat. No. CS-0308262
Purity ≥98%
MDL No. MFCD19704706
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₄N₂
Molecular Weight 150.22
Synonym(s) tetrahydro-1H-Pyrrolizine-7a(5H)-acetonitrile
SMILES C1CC2(CCCN2C1)CC#N

Description

This acetonitrile derivative features a hexahydro-1H-pyrrolizin-7a-yl group that imparts enhanced solubility and metabolic stability. The nitrile moiety enables direct functionalization in synthetic transformations, while the saturated heterocyclic core provides rigidity and favorable pharmacokinetic properties. Ideal for medicinal chemistry campaigns requiring stable, tunable scaffolds.

Application

2-(Hexahydro-1H-pyrrolizin-7a-yl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of nitrogen-containing heterocyclic scaffolds. Its acetonitrile group facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions, while the saturated pyrrolizidine core provides structural rigidity and favorable pharmacokinetic properties. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows.

Synthesis

Route1
- In-stock
  
  40624-07-5
- 372-09-8
- ~53%
- In-stock
  
  78449-75-9
References
- Suzuki, Tomoo; Usui, Toshinao; Oka, Mitsuru; Suzuki, Tsunemasa; Kataoka, Tadashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1265 - 1273
Route2
- 20463-30-3
- 372-09-8
- ~66%
- In-stock
  
  78449-75-9
References
- Miyano, Seiji; Yamashita, Osamu; Fujii, Shinichiro; Somehara, Takao; Sumoto, Kunihiro Heterocycles, 1981 , vol. 16, # 5 p. 755 - 758

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 27.03
LogP 1.52848
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

78449-75-9 sigma78449-75-9 manufacturer78449-75-9 price78449-75-9 structure78449-75-9 SDSbuy 78449-75-978449-75-9 supplier78449-75-9 uses78449-75-9 molecular weightprice of 78449-75-978449-75-9 chemical name formula of 78449-75-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-(Hexahydro-1H-pyrrolizin-7a-yl)acetonitrile

CAS No. 78449-75-9

Recommended Products