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CS-W001157 4
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2-(Azetidin-1-yl)ethan-1-amine

  • CAS No. 795299-77-3

  • Cat. No. CS-0127626
  • Purity≥97%
  • MDL No.MFCD19205720

*For research and further manufacturing use only, not for direct human use.

2-(Azetidin-1-yl)ethan-1-amine|CS-0127626

Structure of 795299-77-3

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General Information

  • CAS No. 795299-77-3
  • Cat. No. CS-0127626
  • Purity ≥97%
  • MDL No. MFCD19205720
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂N₂
  • Molecular Weight 100.16
  • Synonym(s) 2-(azetidin-1-yl)ethanamine
  • SMILES NCCN1CCC1

Description

2-(Azetidin-1-yl)ethan-1-amine features a flexible ethylene linker connecting a primary amine to a strained azetidine ring, imparting enhanced nucleophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for modulating solubility and target engagement.

Application

2-(Azetidin-1-yl)ethan-1-amine serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of constrained heterocyclic scaffolds. Its primary amine and azetidine ring offer complementary reactivity for conjugate additions, amide couplings, and cyclization reactions. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis workflows in API development and target-oriented compound libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H225-H302-H318
Precautionary Statements : P210-P233-P241-P242-P243-P261-P280

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   -0.3492
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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