Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate

  • CAS No. 808137-94-2

  • Cat. No. CS-B0498
  • Purity≥98%
  • MDL No.MFCD09864656

*For research and further manufacturing use only, not for direct human use.

Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate|CS-B0498

Structure of 808137-94-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 808137-94-2
  • Cat. No. CS-B0498
  • Purity ≥98%
  • MDL No. MFCD09864656
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₂
  • Molecular Weight 176.17
  • Synonym(s) Methyl-1H-pyrrolo[2,3-b]pyridin-3-carboxylat
  • SMILES O=C(OC)C1=CNC2=NC=CC=C12

Description

Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate features a fused heterocyclic core with a strategically positioned ester group, enabling direct incorporation into medicinal chemistry campaigns. The electron-deficient pyrrolopyridine scaffold provides enhanced reactivity in transition metal-catalyzed couplings and serves as a privileged building block for kinase inhibitors and CNS-targeted therapeutics.

Application

Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. Its pyrrolopyridine core enables efficient functionalization at the C3 position via cross-coupling or electrophilic substitution, while the ester group supports further derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development and scaffold diversification.

Synthesis

  • Route1

    References

    • WO2004/111048 A1, ; Page 40 ;
  • Route2
    • null|null
      67-56-1
    • 2,2,2-Trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone|CS-M0743
      163220-69-7
    • ~86%
    • In-stock
      Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate|CS-B0498
      808137-94-2

    References

    • VERTEX PHARMACEUTICALS INCORPORATED Patent: WO2005/28475 A2, 2005 ; Location in patent: Page/Page column 131-132 ; WO 2005/028475 A2
  • Route3
    • Methyl 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate|CS-B1128
      245064-81-7
    • ~64%
    • In-stock
      Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate|CS-B0498
      808137-94-2

    References

    • Chaulet, Charlotte; Croix, Cecile; Basset, Joan; Pujol, Maria-Dolores; Viaud-Massuard, Marie-Claude Synlett, 2010 , # 10 p. 1481 - 1484

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   54.98
  • LogP   1.3495
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 808137-94-2 sigma808137-94-2 manufacturer808137-94-2 price808137-94-2 structure808137-94-2 SDSbuy 808137-94-2808137-94-2 supplier808137-94-2 uses808137-94-2 molecular weightprice of 808137-94-2808137-94-2 chemical name formula of 808137-94-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label