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Structure of 81166-84-9
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Cyclopropyl(trimethylsilyl)acetylene is a bench-stable, moisture-tolerant alkyne reagent featuring a sterically protected silyl group and a strained cyclopropyl ring. This combination enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with high regioselectivity. The molecule integrates seamlessly into bioconjugation workflows and complex molecular scaffolds where stability and predictable reactivity are essential.
Cyclopropyl(trimethylsilyl)acetylene serves as a valuable building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted alkynes under mild conditions. Its silyl group provides enhanced stability and facilitates selective deprotection, while the cyclopropyl moiety imparts unique steric and electronic properties beneficial for constructing complex molecular architectures. The compound exhibits excellent bench stability and compatibility with a range of functional groups, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: