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Structure of 82454-61-3
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5-Ethynylpyridin-2-amine features a pyridine ring bearing both an ethynyl group and a primary amine at the 5- and 2-positions, respectively. This bifunctional architecture enables direct incorporation into click chemistry workflows, particularly CuAAC reactions. The electron-deficient pyridine enhances reactivity in conjugation processes while maintaining bench-stability under standard conditions.
5-Ethynylpyridin-2-amine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated heterocyclic systems. The terminal alkyne group facilitates Sonogashira and CuAAC transformations, while the pyridin-2-amine moiety provides a readily functionalizable nitrogen site for derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for constructing bioactive scaffolds and advanced intermediates in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: