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Structure of 82671-03-2
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Ethyl 2,6-dichloro-5-fluoronicotinate features a trifunctional heterocyclic core with strategically positioned electron-withdrawing chlorine and fluorine substituents. This configuration enhances reactivity in cross-coupling processes while maintaining stability under standard conditions. The ester group enables direct incorporation into complex molecular architectures without additional activation.
Ethyl 2,6-dichloro-5-fluoronicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocyclic scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal halogen reactivity profile—combining chlorine for stable coupling and fluorine for directed functionalization—facilitates modular diversification. The ester functionality supports further transformations, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: