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Structure of 82995-06-0
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6-Bromo-8-fluoronaphthalen-2-ol features a naphthalene core bearing bromo and fluoro substituents at the 6- and 8-positions, respectively, with a phenolic hydroxyl group at C2. This electron-deficient scaffold enables direct coupling reactions and serves as a key building block in medicinal chemistry and materials synthesis.
6-Bromo-8-fluoronaphthalen-2-ol serves as a versatile building block for the synthesis of functionalized naphthalene scaffolds, enabling palladium-catalyzed cross-coupling reactions due to its ortho-halogen substitution pattern. The phenolic hydroxyl group provides a handle for derivatization and enhances solubility in polar solvents, while the fluorine atom offers moderate electron-withdrawing character and contributes to metabolic stability in downstream applications. This compound exhibits good bench stability and facilitates purification via recrystallization or column chromatography, making it suitable for use in medicinal chemistry and materials science workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: