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Structure of 832740-73-5
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4-(Isoxazol-5-yl)aniline integrates a bioisosteric isoxazole ring with an aromatic amine, delivering enhanced metabolic stability and improved solubility in polar organic solvents. This scaffold enables efficient coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials.
4-(Isoxazol-5-yl)aniline serves as a versatile building block for heterocyclic scaffolds in medicinal chemistry, enabling direct incorporation into biaryl systems via standard coupling reactions. The isoxazole moiety provides enhanced metabolic stability and polarity, while the aniline functionality offers ready derivatization through electrophilic substitution or amide formation. Bench-stable and readily purified by column chromatography, it functions efficiently in Suzuki-Miyaura, Ullmann, and Buchwald-Hartwig couplings, facilitating rapid access to diverse target molecules in API development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: