Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

  • CAS No. 848133-76-6

  • Cat. No. CS-0001077
  • Molecule weight289.72
  • Purity≥97%
  • MDL No.MFCD09263704

*For research and further manufacturing use only, not for direct human use.

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide|CS-0001077

Structure of 848133-76-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 848133-76-6
  • Cat. No. CS-0001077
  • Purity ≥97%
  • MDL No. MFCD09263704
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂ClN₃O₂
  • Molecular Weight 289.72
  • Synonym(s) N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide
  • SMILES N#CC1=C(Cl)C2=CC(NC(C)=O)=C(OCC)C=C2N=C1

Description

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide features a quinoline core with strategically positioned electron-withdrawing chloro and cyano groups, enhancing reactivity for downstream functionalization. The ethoxy substituent improves solubility in organic media, while the acetamide moiety provides a stable handle for conjugation. This compound serves as a key intermediate in the synthesis of advanced pharmaceutical agents and functional materials.

Application

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide serves as a versatile building block in the synthesis of quinoline-based pharmaceutical intermediates. Its electron-deficient quinoline core enables efficient palladium-catalyzed coupling reactions, while the acetyl group offers a handle for further functionalization. The molecule exhibits good bench stability and facilitates purification via standard chromatographic methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide|CS-0001164
      848133-75-5
    • ~94%
    • In-stock
      N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide|CS-0001077
      848133-76-6

    References

    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd. Patent: US2011/263860 A1, 2011 ; Location in patent: Page/Page column 8 ;
  • Route2
    • null|null
      1201080-09-2
    • ~88%
    • In-stock
      N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide|CS-0001077
      848133-76-6

    References

    • Mao, Yongjun; He, Yang; Zhu, Fuqiang; Chen, Weiming; Shen, Jingshan; Li, Jianfeng Heterocycles, 2014 , vol. 89, # 5 p. 1203 - 1209
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 4 p. 1107 - 1131

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   75.01
  • LogP   3.11698
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 848133-76-6 sigma848133-76-6 manufacturer848133-76-6 price848133-76-6 structure848133-76-6 SDSbuy 848133-76-6848133-76-6 supplier848133-76-6 uses848133-76-6 molecular weightprice of 848133-76-6848133-76-6 chemical name formula of 848133-76-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label