6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile

Name: 6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile
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CAS No. 848139-78-6
Cat. No. CS-M0299
Purity≥98%
MDL No.MFCD12032114

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6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile|CS-M0299

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Description

6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile features a quinoline core bearing an electron-deficient carbonitrile at C3, an ethoxy group at C7, and a chlorinated pyridylmethoxy-substituted aniline moiety. This scaffold integrates a hydrogen-bond donor (amino) and acceptor (nitrile), enabling targeted interactions in kinase inhibition studies. The compound exhibits bench-stable handling under standard conditions and demonstrates enhanced solubility in polar organic solvents due to the balanced polarity of its functional groups.

Application

6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile serves as a versatile building block for medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents. Its core quinoline scaffold enables robust functionalization, while the pyridin-2-ylmethoxy and amino substituents provide orthogonal reactivity for downstream coupling reactions. The molecule exhibits excellent bench stability and facilitates efficient purification via standard chromatographic methods, making it well-suited for high-throughput synthesis workflows.

General Information

CAS No. 848139-78-6
Cat. No. CS-M0299
Purity ≥98%
MDL No. MFCD12032114
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀ClN₅O₂
Molecular Weight 445.90
Synonym(s) 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-ethoxy-quinoline-3-carbonitrile
SMILES N#CC1=C(NC2=CC(Cl)=C(OCC3=NC=CC=C3)C=C2)C(C(N=C1)=C4)=CC(N)=C4OCC

Computational Chemistry Data

TPSA 106.08
LogP 5.45838
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 7

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ether

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

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6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile

CAS No. 848139-78-6

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