tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate

Name: tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 849203-60-7
Cat. No. CS-0007689
Molecule weight239.31
Purity≥97%
MDL No.MFCD14585368

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tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate|CS-0007689

Structure of 849203-60-7

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General Information

CAS No. 849203-60-7
Cat. No. CS-0007689
Purity ≥97%
MDL No. MFCD14585368
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₁NO₃
Molecular Weight 239.31
Synonym(s) 1-Oxo-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester
SMILES O=C(N(CC1)CCC21CCC2=O)OC(C)(C)C

Description

tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate is a sterically shielded spirocyclic ketone bearing a bench-stable tert-butyl ester handle. This scaffold integrates a rigid, electron-deficient lactam core with enhanced solubility in organic media. It enables efficient access to complex nitrogen-containing heterocycles via modular transformations under standard conditions.

Application

tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and synthetic methodology development. The protected ketone and tertiary amine functionalities enable selective transformations, including reductive amination and nucleophilic addition, while the tert-butyl ester facilitates straightforward deprotection under mild acidic conditions. Its rigid, three-dimensional structure enhances binding selectivity in target-directed synthesis and supports efficient route optimization in multi-step sequences.

Synthesis

Route1
- 849203-59-4
- ~%
- In-stock
  
  849203-60-7
References
- US2005/70609 A1, ; Page/Page column 55; 65 ; US 20050070609 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 46.61
LogP 2.3666
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate

CAS No. 849203-60-7

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