4-Chloro-3,5-difluoropyridine

Name: 4-Chloro-3,5-difluoropyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 851178-97-7
Cat. No. CS-W018166
Purity≥96%
MDL No.MFCD09998885

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-3,5-difluoropyridine|CS-W018166

Structure of 851178-97-7

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Description

4-Chloro-3,5-difluoropyridine features a highly electron-deficient pyridine core flanked by strategically positioned fluorine and chlorine substituents, enabling selective cross-coupling reactions under mild conditions. This bench-stable heterocycle integrates efficiently into pharmaceutical intermediates and functional materials, offering enhanced reactivity in Pd-catalyzed transformations.

Application

4-Chloro-3,5-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its electron-deficient pyridine core enhances reactivity in nucleophilic substitution processes, while the orthogonal halogenation pattern allows for sequential derivatization. The compound exhibits excellent bench stability and facilitates clean purification, making it well-suited for scalable synthesis of bioactive heterocycles and API intermediates.

General Information

CAS No. 851178-97-7
Cat. No. CS-W018166
Purity ≥96%
MDL No. MFCD09998885
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂ClF₂N
Molecular Weight 149.53
Synonym(s) None
SMILES FC1=CN=CC(F)=C1Cl

Computational Chemistry Data

TPSA 12.89
LogP 2.0132
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-3,5-difluoropyridine

CAS No. 851178-97-7

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