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Structure of 857292-66-1
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6-Cyclopropylpyridin-2-amine features a cyclopropyl group at the 6-position of pyridin-2-amine, enhancing lipophilicity and metabolic stability. This scaffold integrates readily into kinase inhibitors and bioactive molecules, offering improved membrane permeability and target engagement in medicinal chemistry applications.
6-Cyclopropylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine nitrogen and primary amine functionality offer orthogonal reactivity for sequential derivatization. The cyclopropyl group enhances metabolic stability and modulates electronic properties, contributing to favorable pharmacokinetic profiles. Bench-stable and readily purified by chromatography, it functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and amide coupling protocols, supporting efficient synthesis of target molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: