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CS-W001157 4
Total: USD 88.00

2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine

  • CAS No. 85730-36-5

  • Cat. No. CS-0045811
  • Purity≥97%
  • MDL No.MFCD11558917

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine|CS-0045811

Structure of 85730-36-5

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General Information

  • CAS No. 85730-36-5
  • Cat. No. CS-0045811
  • Purity ≥97%
  • MDL No. MFCD11558917
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₃N₃
  • Molecular Weight 197.55
  • Synonym(s) 4-Amino-2-chloro-6-trifluoromethylpyrimidine
  • SMILES ClC1=NC(=CC(=N1)N)C(F)(F)F

Description

2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability. This pyrimidine scaffold integrates readily into kinase inhibitors and pharmaceutical intermediates, offering high reactivity in cross-coupling and nucleophilic substitution reactions under standard conditions.

Application

2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its reactivity facilitates nucleophilic substitution at the C2 position, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The amine functionality supports diverse coupling reactions, making it well-suited for modular synthesis of kinase inhibitors and other bioactive compounds. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
  • Route2
    • null|null
      85730-34-3
    • ~%
    • In-stock
      2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine|CS-0045811
      85730-36-5

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
  • Route3
    • null|null
      85730-37-6
    • ~%
    • In-stock
      2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine|CS-0045811
      85730-36-5

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.731
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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