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CS-W001157 4
Total: USD 88.00

4-Bromo-2-(trifluoromethyl)benzaldehyde

  • CAS No. 861928-27-0

  • Cat. No. CS-W009464
  • Molecule weight253.02
  • Purity≥97%
  • MDL No.MFCD09037472

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-(trifluoromethyl)benzaldehyde|CS-W009464

Structure of 861928-27-0

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General Information

  • CAS No. 861928-27-0
  • Cat. No. CS-W009464
  • Purity ≥97%
  • MDL No. MFCD09037472
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrF₃O
  • Molecular Weight 253.02
  • Synonym(s) 5-Bromo-2-formylbenzotrifluoride, 4-Bromo-alpha,alpha,alpha-trifluoro-o-tolualdehyde
  • SMILES FC(F)(F)C1=C(C=O)C=CC(Br)=C1

Description

4-Bromo-2-(trifluoromethyl)benzaldehyde features a trifluoromethyl group flanking a brominated aromatic ring, delivering enhanced electron-withdrawing character and stability. This aldehyde integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of pharmaceuticals and functional materials.

Application

4-Bromo-2-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura and Stille couplings due to its orthogonal reactivity profile. The aldehyde group facilitates direct functionalization via nucleophilic addition or condensation reactions, while the bromo and trifluoromethyl substituents offer complementary handles for cross-coupling and enhanced metabolic stability. Bench-stable and amenable to standard purification techniques, it functions reliably in multi-step syntheses of bioactive heterocycles and advanced intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.2804
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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