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CS-W001157 4
Total: USD 88.00

2-Amino-2-(naphthalen-1-yl)ethanol

  • CAS No. 86217-42-7

  • Cat. No. CS-0091303
  • Molecule weight187.24
  • Purity≥97%
  • MDL No.MFCD08752774

*For research and further manufacturing use only, not for direct human use.

2-Amino-2-(naphthalen-1-yl)ethanol|CS-0091303

Structure of 86217-42-7

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General Information

  • CAS No. 86217-42-7
  • Cat. No. CS-0091303
  • Purity ≥97%
  • MDL No. MFCD08752774
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃NO
  • Molecular Weight 187.24
  • Synonym(s) b-Amino-1-naphthaleneethanol
  • SMILES NC(C1=CC=CC2=C1C=CC=C2)CO

Description

2-Amino-2-(naphthalen-1-yl)ethanol features a rigid naphthyl scaffold paired with a benzylic amine and hydroxyl group, enabling dual hydrogen-bonding interactions. This structural motif supports its use in chiral ligand design and as a building block for bioactive heterocycles under standard conditions.

Application

2-Amino-2-(naphthalen-1-yl)ethanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and amino-alcohol scaffolds. Its naphthyl moiety imparts structural rigidity and π-conjugation, while the primary amine and secondary alcohol functionalities offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it suitable for use in solid-phase synthesis and lead optimization campaigns.

Synthesis

  • Route1

    References

    • Planas, Loic; Perard-Viret, Joelle; Royer, Jacques; Selkti, Mohamed; Thomas, Alain Synlett, 2002 , # 10 p. 1629 - 1632
  • Route2
    • null|null
      86217-77-8
    • ~53%
    • In-stock
      2-Amino-2-(naphthalen-1-yl)ethanol|CS-0091303
      86217-42-7

    References

    • Pirkle, William H.; Simmons, Kirk A. Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527
  • Route3

    References

    • Pirkle, William H.; Simmons, Kirk A. Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.8319
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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