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Structure of 869481-93-6
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trans-tert-Butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate features a rigid, conformationally constrained pyrrolidine core with a fluoro substituent at C3 and a hydroxyl group at C4. This configuration enables selective functionalization in complex molecule synthesis, particularly in medicinal chemistry scaffolds requiring stereocontrolled access to fluorinated heterocycles. The tert-butyl ester facilitates straightforward deprotection under mild acidic conditions.
trans-tert-Butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling the construction of fluorinated pyrrolidine scaffolds found in bioactive molecules. The hydroxyl group facilitates downstream functionalization via etherification, esterification, or oxidation, while the tert-butyl carbamate offers excellent stability and ease of removal under mild acidic conditions. The trans stereochemistry ensures predictable reactivity in stereoselective transformations, making it ideal for synthesis of peptide mimetics and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: