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Structure of 884494-38-6
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1-Bromo-3,5-difluoro-2-nitrobenzene features a highly reactive aryl halide scaffold flanked by electron-withdrawing fluorine and nitro groups, enabling efficient coupling in cross-coupling reactions. The para-nitro substitution enhances electrophilicity, while the meta-fluorines offer orthogonal reactivity for sequential functionalization. This bench-stable, moisture-tolerant reagent integrates seamlessly into complex molecule synthesis.
1-Bromo-3,5-difluoro-2-nitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its ortho-bromine functionality. The electron-withdrawing nitro and difluoro groups enhance reactivity while maintaining bench stability and compatibility with diverse functional groups, facilitating efficient construction of complex heterocyclic scaffolds and substituted biaryls under standard reaction conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: