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CS-W001157 4
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6-Fluoro-2-methylnicotinaldehyde

  • CAS No. 884494-96-6

  • Cat. No. CS-0136037
  • Purity≥98%
  • MDL No.MFCD05662399

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-2-methylnicotinaldehyde|CS-0136037

Structure of 884494-96-6

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General Information

  • CAS No. 884494-96-6
  • Cat. No. CS-0136037
  • Purity ≥98%
  • MDL No. MFCD05662399
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) 6-fluoro-2-methyl-pyridine-3-carbaldehyde
  • SMILES O=CC1=C(C)N=C(F)C=C1

Description

6-Fluoro-2-methylnicotinaldehyde delivers a strategically positioned fluorine atom and methyl group on the nicotinaldehyde scaffold, enabling precise tuning of electronic properties and steric profile. This configuration enhances reactivity in coupling processes and supports efficient incorporation into bioactive heterocycles under standard conditions.

Application

6-Fluoro-2-methylnicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its ortho-methyl and meta-fluoro substituents provide enhanced reactivity and metabolic stability, facilitating downstream functionalization via nucleophilic addition, condensation, or coupling reactions. The aldehyde group offers high synthetic versatility for amine-based conjugation, imine formation, and scaffold diversification. Bench-stable and readily purified, it supports scalable synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.34162
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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