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CS-W001157 4
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3-Fluoro-2-methylbenzamide

  • CAS No. 886502-05-2

  • Cat. No. CS-0061158
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methylbenzamide|CS-0061158

Structure of 886502-05-2

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General Information

  • CAS No. 886502-05-2
  • Cat. No. CS-0061158
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO
  • Molecular Weight 153.15
  • Synonym(s) None
  • SMILES CC1=C(C(N)=O)C=CC=C1F

Description

3-Fluoro-2-methylbenzamide features a fluorinated aromatic ring paired with a methyl group at adjacent positions, delivering enhanced metabolic stability and favorable lipophilicity. This structural motif enables direct incorporation into bioactive molecules for medicinal chemistry campaigns, particularly in kinase inhibitor and CNS-targeted compound development.

Application

3-Fluoro-2-methylbenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its ortho-substituted aryl amide framework offers enhanced metabolic stability and modulates electronic properties for targeted receptor interactions. The molecule exhibits excellent bench stability, facilitates straightforward purification via crystallization, and demonstrates broad compatibility with standard coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.23302
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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