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tert-Butyl 2-isopropylpiperazine-1-carboxylate

  • CAS No. 886766-25-2

  • Cat. No. CS-W009252
  • Purity≥95%
  • MDL No.MFCD08273957

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-isopropylpiperazine-1-carboxylate|CS-W009252

Structure of 886766-25-2

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General Information

  • CAS No. 886766-25-2
  • Cat. No. CS-W009252
  • Purity ≥95%
  • MDL No. MFCD08273957
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄N₂O₂
  • Molecular Weight 228.33
  • Synonym(s) 1-N-Boc-2-isopropylpiperazine
  • SMILES O=C(N1C(C(C)C)CNCC1)OC(C)(C)C

Description

tert-Butyl 2-isopropylpiperazine-1-carboxylate features a sterically hindered piperazine core with a tert-butyl ester protecting group, enabling stable handling and selective deprotection under mild acidic conditions. The isopropyl substituent enhances solubility in organic media while maintaining compatibility with diverse synthetic transformations. This derivative serves as a key intermediate in the construction of bioactive molecules requiring nitrogen-rich scaffolds.

Application

tert-Butyl 2-isopropylpiperazine-1-carboxylate serves as a versatile piperazine-based building block in medicinal chemistry, enabling the synthesis of diverse nitrogen-containing scaffolds. The tert-butyl carbamate group offers excellent bench stability and facile removal under mild acidic conditions, while the isopropyl substituent provides steric bulk and enhanced solubility. It functions effectively in standard coupling reactions and serves as a key intermediate in the construction of bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.8513
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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