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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-imidazol-4-amine hydrochloride

  • CAS No. 89088-69-7

  • Cat. No. CS-W005721
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD21340310

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-imidazol-4-amine hydrochloride|CS-W005721

Structure of 89088-69-7

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General Information

  • CAS No. 89088-69-7
  • Cat. No. CS-W005721
  • Purity ≥97%
  • MDL No. MFCD21340310
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClN₃
  • Molecular Weight None
  • Synonym(s) 1H-Imidazol-4-amine, 1-methyl-, monohydrochloride
  • SMILES CN(C=N1)C=C1N.Cl

Description

1-Methyl-1H-imidazol-4-amine hydrochloride features a protonated imidazole nitrogen enabling enhanced solubility and reactivity in aqueous synthesis. This bench-stable, moisture-tolerant amine serves as a key building block for bioactive heterocycles, particularly in medicinal chemistry and ligand design.

Application

1-Methyl-1H-imidazol-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to imidazole-based scaffolds. Its well-defined reactivity facilitates direct functionalization at the 4-position and compatibility with standard coupling protocols. The hydrochloride salt enhances bench stability and simplifies purification, making it suitable for use in multi-step syntheses of bioactive compounds and heterocyclic intermediates.

Synthesis

  • Route1
    • 4-Amino-1-methylimidazole|CS-0021854
      79578-98-6
    • ~%
    • In-stock
      1-Methyl-1H-imidazol-4-amine hydrochloride|CS-W005721
      89088-69-7

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin Patent: WO2010/38060 A1, 2010 ; Location in patent: Page/Page column 84 ; WO 2010/038060 A1
  • Route2
    • 1-Methyl-4-nitroimidazole Metronidazole  Impurity|CS-0229039
      3034-41-1
    • ~97%
    • In-stock
      1-Methyl-1H-imidazol-4-amine hydrochloride|CS-W005721
      89088-69-7

    References

    • Su, Qibin; Ioannidis, Stephanos; Chuaqui, Claudio; Almeida, Lynsie; Alimzhanov, Marat; Bebernitz, Geraldine; Bell, Kirsten; Block, Michael; Howard, Tina; Huang, Shan; Huszar, Dennis; Read, Jon A.; Rivard Costa, Caroline; Shi, Jie; Su, Mei; Ye, Minwei; Zinda, Michael Journal of Medicinal Chemistry, 2014 , vol. 57, # 1 p. 144 - 158

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.4241
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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