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CS-W001157 4
Total: USD 88.00

(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetic acid

  • CAS No. 89336-46-9

  • Cat. No. CS-W001880
  • Purity≥97%
  • MDL No.MFCD02682394

*For research and further manufacturing use only, not for direct human use.

(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetic acid|CS-W001880

Structure of 89336-46-9

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General Information

  • CAS No. 89336-46-9
  • Cat. No. CS-W001880
  • Purity ≥97%
  • MDL No. MFCD02682394
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂O₄S
  • Molecular Weight 258.29
  • Synonym(s) N-Boc-2-amino-4-thiazolacetic Acid
  • SMILES O=C(Nc1scc(n1)CC(=O)O)OC(C)(C)C

Description

This thiazole-based amino acid derivative features a tert-butoxycarbonyl-protected amine and a carboxylic acid group, enabling straightforward incorporation into peptide synthesis workflows. The electron-deficient thiazole ring enhances stability and facilitates selective derivatization under standard conditions.

Application

(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetic acid serves as a versatile building block for thiazole-containing peptide mimetics and medicinal chemistry libraries. The tert-butyl carbamate group provides stable protection of the amine under standard reaction conditions, enabling selective deprotection during late-stage functionalization. The acetic acid moiety facilitates conjugation via ester or amide formation, while the thiazole ring offers structural rigidity and metabolic stability. This compound enables efficient access to bioactive scaffolds through established coupling protocols and is compatible with common purification methods.

Synthesis

  • Route1
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      103053-96-9
    • ~%
    • In-stock
      (2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetic acid|CS-W001880
      89336-46-9

    References

    • US5773411 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   88.52
  • LogP   2.1172
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   3

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