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CS-W001157 4
Total: USD 88.00

5-Cyclopropylpyridin-2-amine

  • CAS No. 893738-68-6

  • Cat. No. CS-W022369
  • Purity≥95%
  • MDL No.MFCD06802676

*For research and further manufacturing use only, not for direct human use.

5-Cyclopropylpyridin-2-amine|CS-W022369

Structure of 893738-68-6

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General Information

  • CAS No. 893738-68-6
  • Cat. No. CS-W022369
  • Purity ≥95%
  • MDL No. MFCD06802676
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight None
  • Synonym(s) 2-Amino-5-cyclopropylpyridine
  • SMILES NC1=NC=C(C2CC2)C=C1

Description

5-Cyclopropylpyridin-2-amine features a cyclopropyl group at the 5-position of a pyridine ring, enhancing lipophilicity and metabolic stability. The primary amine at the 2-position enables direct functionalization in medicinal chemistry. This scaffold integrates readily into kinase inhibitors and CNS-targeted compounds due to favorable solubility and membrane permeability under standard conditions.

Application

5-Cyclopropylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine core offers favorable electronic properties and hydrogen-bonding capacity, while the cyclopropyl group enhances metabolic stability and modulates lipophilicity. The amine functionality facilitates straightforward derivatization, and the compound exhibits excellent bench stability and compatibility with common purification methods.

Synthesis

  • Route1

    References

    • Zhang, Min; Cui, Xiuling; Chen, Xiaopei; Wang, Lianhui; Li, Jingya; Wu, Yusheng; Hou, Lifen; Wu, Yangjie Tetrahedron, 2012 , vol. 68, # 3 p. 900 - 905

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5412
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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