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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

  • CAS No. 91526-18-0

  • Cat. No. CS-W004926
  • Purity≥95%
  • MDL No.MFCD12165896
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one|CS-W004926

Structure of 91526-18-0

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Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a bench-stable, moisture-tolerant synthon featuring a reactive α-hydroxycarbonyl moiety. This structure integrates readily into cascade cyclizations and C–C bond-forming sequences, enabling efficient access to functionalized heterocycles under mild conditions.

Application

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one serves as a versatile synthon in medicinal chemistry, enabling efficient access to functionalized heterocyclic scaffolds. Its α,β-unsaturated γ-lactone core facilitates Michael additions and nucleophilic transformations under mild conditions. The hydroxymethyl group provides a handle for further derivatization, while the molecule exhibits good bench stability and compatibility with common protecting group strategies. This compound functions effectively in multi-step synthesis workflows requiring controlled reactivity and predictable regioselectivity.

General Information

  • CAS No. 91526-18-0
  • Cat. No. CS-W004926
  • Purity ≥95%
  • MDL No. MFCD12165896
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₄
  • Molecular Weight 130.10
  • Synonym(s) 4-hydroxymethyl-5-methyl-1,3-dioxol-2-one
  • SMILES CC1=C(CO)OC(=O)O1

Computational Chemistry Data

  • TPSA   63.58
  • LogP   0.03352
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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