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1-Fluoropropan-2-amine hydrochloride

  • CAS No. 921602-78-0

  • Cat. No. CS-0107816
  • Purity≥97%
  • MDL No.MFCD20489620

*For research and further manufacturing use only, not for direct human use.

1-Fluoropropan-2-amine hydrochloride|CS-0107816

Structure of 921602-78-0

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General Information

  • CAS No. 921602-78-0
  • Cat. No. CS-0107816
  • Purity ≥97%
  • MDL No. MFCD20489620
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉ClFN
  • Molecular Weight 113.56
  • Synonym(s) 1-fluoropropan-2-amine HCl
  • SMILES CC(N)CF.[H]Cl

Description

1-Fluoropropan-2-amine hydrochloride is a bench-stable, moisture-tolerant amine reagent featuring a fluorinated alkyl chain that enables selective functionalization in synthetic transformations. This polar, crystalline salt facilitates efficient coupling reactions and serves as a key building block in medicinal chemistry for accessing fluorinated bioactive molecules.

Application

1-Fluoropropan-2-amine hydrochloride serves as a versatile fluorinated amine building block for medicinal chemistry and agrochemical synthesis. Its bench-stable, crystalline form facilitates handling and purification, while the primary amine functionality enables straightforward derivatization via amidation, alkylation, and coupling reactions. The fluorine substituent imparts enhanced metabolic stability and modulates lipophilicity, making it valuable in optimizing pharmacokinetic properties of target molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.7249
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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